Treatment of Stable Angina of Effort with Verapamil : A Double - blind , Placebo - controlled Randomized Crossover Study SAMUEL
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چکیده
a double-blind, placebo-controlled, randomized crossover protocol using serial treadmill tests. Verapamil, 480 mg/day, reduced anginal frequency from 5.6 + 7.3 to 2.2 ± 3.9 attacks per week (p < 0.001) and nitroglycerin consumption from 3.4 ± 4.9 to 1.2 ± 2.5 tablets.per week (p < 0.05) compared with placebo. Treadmill time increased from 6.4 ± 2.1 minutes during the placebo phase to 7.5 ± 1.8 minutes during the
منابع مشابه
Treatment of stable angina of effort with verapamil: a double-blind, placebo-controlled randomized crossover study.
The effects of verapamil were assessed in 26 patients with stable exertional angina pectoris in a double-blind, placebo-controlled, randomized crossover protocol using serial treadmill tests. Verapamil, 480 mg/day, reduced anginal frequency from 5.6 +/- 7.3 to 2.2 +/- 3.9 attacks per week (p less than 0.001) and nitroglycerin consumption from 3.4 +/- 4.9 to 1.2 +/- 2.5 tablets per week (p less ...
متن کاملA double-blind randomized trial of propranolol and verapamil in the treatment of effort angina.
In 18 patients with stable effort angina, verapamil, 80 mg four times daily, was compared with propranolol, 80 mg four times daily, in a double-blind, placebo-controlled trial to assess the effects on anginal threshold, exercise capacity and left ventricular function measured by gated equilibrium blood pool scanning. Both propranolol and verapamil improved exercise capacity (placebo 424 +/- 135...
متن کاملVerapamil versus placebo in relieving stable angina pectoris.
Verapamil and placebo were compared in patients with stable, effort-induced angina. Single-blind dose titration (240, 360 and 480 mg/day) preceded a double-blind crossover. Among the 18 patients who completed graded exercise stress tests with reproducible pretreatment effort-limiting angina, exercise duration increased from 348 +/- 127 seconds (SD) before treatment to 494 +/- 182 seconds after ...
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BACKGROUND Sublingual nitroglycerin increases exercise duration in patients with stable angina. Brief results from this study were published previously in German. Here, we more fully describe the study methodology, patient characteristics, and detailed results. METHODS This double-blind, crossover study enrolled 51 patients with stable angina. Patients were randomized to 1 of 5 treatment sequ...
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Fatigue is recognized as one of the most disabling and frequent symptoms of multiple sclerosis (MS). Amantadine appears to have some proven ability to alleviate the fatigue in MS. The aim of this study was to assess the efficacy of co-administration of amantadine and aspirin for the treatment of fatigue in multiple sclerosis. Forty-five ambulatory patients aged 20–50 years with a diagnosis of M...
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تاریخ انتشار 2005